TISSUE THIAMINE IN HEMORRHAGIC SHOCK 12

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Abstract
The thiamine and cocarboxylase content of liver, muscle and kidneys was detd. before and after hemorrhagic shock was induced in dogs, most of which had previously been fortified with parenteral thiamine injections. In 8 of 9 animals, total liver thiamine conc. rose after shock was induced; the extent of the rise was roughly proportional to the duration of shock. Five control animals showed no significant change. Although the total thiamine content of the muscle showed no striking change during shock, the free thiamine increased markedly at the expense of muscle cocarboxylase. This was interpreted as an in vivo phosphatase splitting of cocarboxylase as a result of the tissue anoxia occurring in shock and was comparable to the same changes which are known to occur in vitro. Various possible explanations for the rise in liver thiamine in shock are given.

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