NEOPLASTIC ANGIOENDOTHELIOSIS WITH LYMPHOCYTE-B MARKERS ON NEOPLASTIC-CELLS - A CASE-REPORT

  • 1 January 1985
    • journal article
    • research article
    • Vol. 76  (3) , 208-212
Abstract
Neoplastic angioendotheliosis (NAE) is a rare disease characterized by the occlusion of small vessels by apparently neoplastic medium-sized cells. The origin of these cells remains undetermined, mainly because the diagnosis in most of these cases has been made on autopsy. This report describes a case of NAE from whom a biopsy specimen was obtained and studied immunohistologically. The cells occluding small vessels of this patient bear B cell markers such as monoclonal immunoglobulin (.mu., .lambda.), Leu14, B1, OKB2, and Dako-PanB, whereas they do not react with antibodies against .delta.-chain and .kappa.-chain of immunoglobulin (Ig), or antibodies against markers of T cells, myelomonocytic cells and endothelial cells. The cells occluding the small vessels of this patient are apparently neoplastic and of B cell lineage. This is the 1st case of NAE in whom the neoplastic cells in the blood vessels have been proved to be of lymphocytic lineage.

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