Essential Role of Megalin in Renal Proximal Tubule for Vitamin Homeostasis

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Abstract
Two major aspects concerning the reabsorption process are still unclear, namely: (1) the molecular basis for the efficient clearance of protein from the tubular fluid, and (2) the physiologic rationale for it, since the amounts of amino acids lost in the urine due to glomerular filtration of peptides and proteins would probably otherwise be of minor importance in the overall protein metabolism. In this review, we shall try at least in part to answer these two questions, introducing a major receptor for endocytic clearance of proteins in the tubular fluid and demonstrating the general importance of this reabsorption for vitamin homeostasis.

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