Recurrent neuroblastoma: the role of CT and alternative imaging tests.

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Abstract
A total of 112 CT scans of 52 patients who were receiving treatment for neuroblastoma were reviewed for accuracy, and findings were correlated with data obtained from other imaging tests, physical examinations, laboratory tests, biopsies, surgery and long-term clinical follow-up. CT was the most sensitive imaging test for tumor recurrence (85% detection rate), and it was also the most versatile in the retroperitoneum, liver, cranium, mediastinum, lymph nodes and skeleton. All 30 tumor recurrences were detected by the combination of CT, bone-marrow biopsy and selected spot radiographs at the sites of pain. CT was accurate and clinically useful both for assessing tumor response to therapy and for predicting findings at 2nd look surgery (accuracy, 94%). CT is relatively cost effective by substituting for a more expensive but less accurate combination of competitive imaging studies.

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