Epithelial‐myoepithelial duct carcinoma of salivary glands: a follow‐up and cytophotometric study of 21 cases

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Abstract
The Salivary Gland Registry provided 21 cases of epithelial-myoepithelial duct carcinoma of salivary glands from 1965-1980 which were evaluated retrospectively for clinical follow-up and cytophotometric data; 81% were localized in the major, 19% in the minor salivary glands. The male: female ratio was 1:1:1, 10 patients (47.6%) being men and 11 (52.4%) women. The youngest patient was 27, the oldest 91 y old. The mean age was 59.3 y (overall), 57.9 y (women) and 61.0 (men). The clinical course was characterized by lymph node metastases present at initial diagnosis and local recurrences in 23.5%. No patient died of the tumor. In 12 cases, cytochemical assessment of nuclear DNA by means of single cell scanning cytophotometry yielded diploid histograms. According to clinical and cytophotometrical data, epithelial-myoepithelial duct carcinoma of salivary glands can be regarded as a prooper tumor entity of low grade malignancy.