DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.
Open Access
- 1 March 1990
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 171 (3) , 965-970
- https://doi.org/10.1084/jem.171.3.965
Abstract
To study the potential involvement of IL-6 in the development of plasmacytomas, a number of plasmacytoma lines were analyzed for alterations in the IL-6 locus. A DNA rearrangement due to the insertion of an intracisternal A particle retrotransposon 18 bp 5'' of the transcriptional start site was detected in the cell line MPC11. The IL-6 gene is constitutively expressed in MPC11, suggesting the involvement of IL-6 in the development of certain myeloma/plasmacytomas according to the "autocrine growth hypothesis".This publication has 17 references indexed in Scilit:
- Structure and evolution of mouse interleukin 6 geneMolecular Immunology, 1989
- PARACRINE RATHER THAN AUTOCRINE REGULATION OF MYELOMA-CELL GROWTH AND DIFFERENTIATION BY INTERLEUKIN-61989
- Molecular Regulation of B Lymphocyte ResponseAnnual Review of Immunology, 1988
- cDNA cloning of murine interleukin-HP1: homology with human interleukin 6European Journal of Immunology, 1988
- Autocrine growth factors and cancerNature, 1985
- Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytoma.Proceedings of the National Academy of Sciences, 1984
- Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomasNature, 1983
- Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and menCell, 1983
- Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencingJournal of Molecular Biology, 1980
- SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLSThe Journal of Experimental Medicine, 1970