Detection of persistent coxsackie B virus RNA in dilated cardiomyopathy and myocarditis

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Abstract
Using a virus-specific cDNA hybridisation probe we have detected coxsackie B virus RNA sequences in 14 of 27 endomyocardial biopsy specimens from patients with histopathological evidence of active or healed myocarditis or of dilated cardiomyopathy. No coxsackie B virus-specific sequences were detected in 11 myocardial biopsies in which a viral aetiology was unlikely and the histological diagnosis negative for myocarditis or dilated cardiomyopathy.