EFFECT OF DIAZEPAM ON EXPERIMENTALLY INDUCED PAIN THRESHOLDS
Open Access
- 1 January 1974
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 46 (1) , 50-53
- https://doi.org/10.1093/bja/46.1.50
Abstract
Tibial pressure and thermal pain thresholds were measured under carefully controlled conditions in 16 subjects after the intravenous administration of diazepam, 0.15 mg/kg. Control observations showed no significant change when studied for 1 hour. Infiltration of the skin overlying the tibia did not significantly alter tibial pressure pain thresholds. Diazepam was shown to produce a variable effect both in the direction of the changes in both types of pain threshold and in their timing. In some subjects there was a dissociation between the direction of change of the two types of pain threshold.Keywords
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