CARCINOMA OF AN ADRENO-CORTICAL REST ASSOCIATED WITH HYPOPHYSEAL ABNORMALITY

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Abstract
We record this case not so much because of the rarity of tumours of an adreno-cortical rest but because of the extreme changes present in the hypophysis. While the association of adreno-cortical tumour with hypophyseal abnormality is well known, in no case has such profound hypophyseal change been associated with such a paucity of symptoms. Moreover, we consider the findings, up to a point, capable of explanation. DESCRIPTION OF CASE Clinical history A female shop assistant aged 26 years was seen in July 1940, complaining of an acneform eruption of the face, hirsuties, and coarsening of the features. She had first noticed the acne and the alteration in facial appearance six weeks before. Her previous health had been good and she had no complaints other than concern over the sudden change in her appearance. Her previous menstrual history was normal. She had missed two menstrual periods since the development of

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