Reduced Levels of Serum Haemolytic Complement and Renal Lesions in Ovum‐Fusion‐Derived Tetraparental Mouse Chimaeras

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Abstract
Tetraparental mice of the NZB↔CFW chimaeras were examined for: [I] the degree and location of antibody and complement deposition in the kidneys; [2] the origin of the complement deposited in the kidneys; and [3] serum haemolytic complement levels These data were compared with similar observations on pa rental‐strain mice and other chimaeric combinations The renal lesions showed hath quantitatively and specially increased deposition of antibody and complement in the NZB↔CFW chimaeras compared with the controls In addition, the complement in the kidneys was shown to induce C5 of CFW origin. Finally, serum haemolytic complement in the chimaeras was undetectable despite the fact that CFW mice have rather high levels of haemolytic complement. It is argued that one explanation for these findings could be the presence of chronic allogeneic disease in the chimaeras. Other evidence for the existence of such a state it cited, but it is noted that such findings are not seen in all chimaeric combinations.