Prolonged plasma half‐life after oral isosorbide dinitrate in patients with angina pectoris.
Open Access
- 1 June 1983
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 15 (6) , 746-748
- https://doi.org/10.1111/j.1365-2125.1983.tb01560.x
Abstract
The plasma concentration of isosorbide dinitrate (ISDN) was monitored up to 24 h after a chronic oral dose of 60 mg in six patients with coronary artery disease. A terminal half‐life of 7.7 +/‐ 2.6 h (mean +/‐ s.d.) was observed. The presence of this prolonged disappearance phase provided at least a partial explanation for the observed accumulation of ISDN in plasma after chronic dosing on a six hourly regimen.Keywords
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