Determination of Methaqualone and Its Major Metabolite in Plasma and Saliva After Single Oral Doses*

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Abstract
A gas liquid chromatographic procedure for the determination of methaqualone and metabolite I (2-methyl-3(2-hydroxymethylphenyl)-4(3H)-quinazoline) in plasma and saliva is described. The method requires 1.0 mL of sample and involves internal standard addition, extraction with butyl chloride, chromatography on a 1% SP-1000 column packing using nitrogen phosphorous detectors. Within-run and day-to-day coefficient variations were less than 8% and the procedure has a sensitivity limit of 20 ng/mL. The method has been used to monitor both parent drug and metabolite in plasma and samples collected after a single oral dose.

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