A Gene-Controlled Reaction in Neurospora Involving the Synthesis of Pantothenic Acid

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Abstract
An enzyme system present in wild-type Neurospora which catalyzes the synthesis of pantothenic acid from beta-alanine and pantoyl lactone is demonstrated. Analysis for pantothenic acid with Lactobacillus arabinosus reveals that intact resting mycelium of the pantothenicless mutant of Neurospora produces no pantothenate; however, that of wild type produces considerable amounts of pantothenate in the presence of beta-alanine and pantoyl lactone, and a little in their absence. In vitro expts. with dried mycelium indicate that pantothenate production occurs only in the presence of both of these precursors. The optimal pH lies above 6. The yield of pantothenate is greater with higher concns. of mycelium and exceeds manyfold the amt. extractable from mycelium, although it is somewhat less in vitro than in vivo. It appears that glucose and coenzymes may stimulate the synthesis in vitro.

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