Taxol, a molecule for all seasons
- 26 March 2001
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 10,p. 867-880
- https://doi.org/10.1039/b100070p
Abstract
The diterpenoid natural product taxol, first discovered in the 1960’s has proved to be the most important new anticancer drug introduced in the last ten years. A brief history of taxol’s development from laboratory curiosity to blockbuster drug is followed by a summary of its chemistry, including an overview of the six completed syntheses of taxol. The review concludes with a discussion of its bioactivity as a promoter of tubulin polymerization and as a drug.Keywords
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