MOBILIZATION OF ALKALINE PHOSPHATASE IN THE UTERUS OF THE MOUSE BY ESTROGEN12

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Abstract
A MARKED increase in the amount of alkaline phosphatase present in the uterus of the mouse following administration of estrogen has been reported in a previous paper (Atkinson and Elftman, 1946). The injection of estrogen into the ovariectomized mouse is followed by a pronounced increment of phosphatase in the uterine glands and lumenal epithelium and in the circular layer of the myometrium. Neither androgen nor progesterone produce this effect. The purpose of the experiments here described is to study the relation between the amount of estrogen administered and the degree of mobilization of alkaline phosphatase. These experiments also provide data concerning the time of appearance and the duration of the response. With this information at hand it is possible to bring the alkaline phosphatase mobilizing effect of estrogen into at least temporal relation to its other physiological actions.