EFFECTS OF LITHIUM ON FOOT SHOCK-INDUCED AGGRESSIVE-BEHAVIOR IN RATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 222  (1) , 125-131
Abstract
The effects of LiCl, 1, 2, 3 meq/kg, i.p., were studied on foot shock-induced aggressive behavior categorized as hyperreactivity, pre-attack and actual fight or attack scores in rats. The attack score was significantly decreased at all doses between 2-48 h post-drug intervals. LiCl also antagonized both amphetamine-induced facilitation and scopolamine-induced suppression of the shock-induced aggression; these effects suggest a probable role of Li in normalizing induced disturbances of both central adrenergic and cholinergic mechanisms and may be at least partly responsible for its psychotherapeutic efficacy as a mood normalizer.

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