Inhibition of glyoxalase I by the enediol mimic S-(N-hydroxy-N-methylcarbamoyl)glutathione. The possible basis of a tumor-selective anticancer strategy.
Open Access
- 1 December 1992
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 267 (35) , 24933-24936
- https://doi.org/10.1016/s0021-9258(19)73986-6
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- Caution: The glycylmethyl and glycylethyl esters of glutathione are substrates for glyooxalase IBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1992
- Kinetic parameters for the elimination reaction catalyzed by triosephosphate isomerase and an estimation of the reaction's physiological significanceBiochemistry, 1991
- Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomeraseBiochemistry, 1990
- Optimization of efficiency in the glyoxalase pathwayBiochemistry, 1988
- Inhibition by glutathione derivatives of bovine liver glyoxalase II (hydroxyacylglutathione hydrolase) as a probe of the N- and S-sites for substrate bindingBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986
- Inhibition of mammalian glyoxalase I (lactoylglutathione lyase) by N-acylated S-blocked glutathione derivatives as a probe for the role of the N-site of glutathione in glyoxalase I mechanismBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986
- Glyoxalase II activity in tumoursCellular and Molecular Life Sciences, 1975
- Analog approaches to the structure of the transition state in enzyme reactionsAccounts of Chemical Research, 1972
- Glyoxalase inhibitors. A possible approach to anticancer agentsJournal of Medicinal Chemistry, 1971
- Glyoxalase inhibitors as potential anticancer agentsBiochemical and Biophysical Research Communications, 1969