PHENOTYPING OF SOUTH-AFRICAN BLACK TUBERCULOSIS PATIENTS FOR INACTIVATION OF ISONIAZID

  • 1 January 1979
    • journal article
    • research article
    • Vol. 23  (2) , 243-256
Abstract
Studies of isoniazid inactivation rates in black tuberculosis patients from South Africa and Birmingham, Alabama, USA, showed a higher frequency of fast inactivation than those of North American Caucasian patients. After an oral test dose of 10 mg/kg isoniazid the percentage of fast inactivators in black patients of South Africa and Alabama was close to 60% while in North American white participants (Canadian and Birmingham Caucasians), the frequency of fast inactivation was approximately 40%.