Improved Screening Procedure for Diuretics
- 1 August 1992
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 15 (12) , 2205-2224
- https://doi.org/10.1080/10826079208016335
Abstract
An improved screening procedure for commonly used diuretics in urine samples is described. The diuretics mixture assayed is quickly and satisfactorily resolved using an HP-Hypersil ODS-C18 column and a mobile phase consisting of acetonitrile/phosphate buffer (pH = 3) in gradient elution mode. Alternatively, acetate buffer (pH = 4) is utilized to improve resolution and sensitivity with more acidic compounds such as ethacrynic acid and probenecid.Keywords
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