Metabolism of Volatile Fatty Acids by the Perfused Goat Liver.

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Abstract
Goat livers were perfused for 1 hour with blood containing added carboxyl-C14 labeled acids. Formate, butyrate and propionate were removed from the blood and contributed heavily to carbohydrate metabolism and formation of liver glycogen. Both formate and acetate levels in blood increased. The major portion of the label of acetate remained in the blood acetate showing that most of the acetate passes unaltered through the liver. Little activity was found in the blood acetone bodies although a marked increase in blood acetone bodies occurred, presumably from liver lipids. Appreciable labeling was noted in the liver phosphatide fraction especially from formate and propionate. The conversion of butyrate to lactose observed earlier probably proceeds via carbohydrate produced from butyrate by the liver.

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