Comparative expression pathway analysis of human and canine mammary tumors
Top Cited Papers
Open Access
- 27 March 2009
- journal article
- research article
- Published by Springer Nature in BMC Genomics
- Vol. 10 (1) , 135
- https://doi.org/10.1186/1471-2164-10-135
Abstract
Spontaneous tumors in dog have been demonstrated to share many features with their human counterparts, including relevant molecular targets, histological appearance, genetics, biological behavior and response to conventional treatments. Mammary tumors in dog therefore provide an attractive alternative to more classical mouse models, such as transgenics or xenografts, where the tumour is artificially induced. To assess the extent to which dog tumors represent clinically significant human phenotypes, we performed the first genome-wide comparative analysis of transcriptional changes occurring in mammary tumors of the two species, with particular focus on the molecular pathways involved.Keywords
This publication has 89 references indexed in Scilit:
- Frequent epigenetic inactivation of Wnt antagonist genes in breast cancerBritish Journal of Cancer, 2008
- Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activityProceedings of the National Academy of Sciences, 2007
- New developments in the InterPro databaseNucleic Acids Research, 2007
- Global mapping of c-Myc binding sites and target gene networks in human B cellsProceedings of the National Academy of Sciences, 2006
- Oncogenic pathway signatures in human cancers as a guide to targeted therapiesNature, 2005
- Molecular determinants of resistance to antiandrogen therapyNature Medicine, 2003
- Statistical significance for genomewide studiesProceedings of the National Academy of Sciences, 2003
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002
- KEGG: Kyoto Encyclopedia of Genes and GenomesNucleic Acids Research, 2000
- Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivoNature, 1993