Studies on antitumor cyclic hexapeptides RA obtained from Rubiae Radix, Rubiaceae. VI Minor antitumor constituents.

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Abstract
New antitumor cyclic hexapeptides RA-IV, RA-III, RA-II and RA-I were isolated as minor constituents of Rubia cordifolia. Their structures were elucidated by means of various instrumental and chemical analyses. From a comparison of the antitumor activities of 7 products derived by oxidizing RA-V with 2,3-dichloro-5,6-dicyano-p-benzoquinone and 6 native cyclic hexapeptides isolated from R. cordifolia, it is surmised that the active site in the RA-series is present at the .alpha.-side of RA molecules.

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