Nonoxynol-9 Protects Mice against Vaginal Transmission of Genital Herpes Infections
- 1 October 1993
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 168 (4) , 1009-1011
- https://doi.org/10.1093/infdis/168.4.1009
Abstract
A vaginal application of a commercially available contraceptive jelly containing nonoxynol-9 (N9) prevented vaginal transmission of herpes simplex virus type 2 (HSV-2) infections in the mouse. When N9 jelly was delivered to the vagina with the virus inoculum, 20 s before inoculum, or 5 min before inoculum, mice were completely protected from visible infection (P < .001). Protection lasted for at least 30 min (P < .03), and significant protection occurred even when the N9 jelly was delivered 15 min after the HSV-2 inoculum (P < .05). These results are consistent with results of studies using N9 products in other animal models and suggest that N9-based contraceptive products can provideKeywords
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