Vestibular Hair Cell Pathology Following Low-dose Irradiation during Embryonic Development

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Abstract
Pregnant CBA/CBA mice (total gestational age 20-21 days) were whole-body irradiated on the 12th, 13th and 16th gestational days with single doses of 1 and 2 Gy using a 60Co source. Litters were taken for morphological analysis 14-21 days after birth. Irradiation on the 12th and 13th gestational days was thus performed prior to morphologic inner ear organogenesis and cytodifferentiation. In approximately 20% of the total postnatal vestibular hair cell population cytological alterations were evident: giant cytoplasmic protrusions, sensory hair fusion and disintegration of the cuticular plate. The other parts of the hair cells remained intact, including nerve endings. Morphometry was not performed. Hair cells type I are more vulnerable to ionizing irraidation during cytodifferentiation than hair cells of type II. All investigated animals showed clinically a normal balance and a normal righting reflex.