Inflammatory Response in Enterocolitis in the Piebald Lethal Mouse Model of Hirschsprung's Disease
- 1 August 1988
- journal article
- research article
- Published by Springer Nature in Pediatric Research
- Vol. 24 (2) , 152-155
- https://doi.org/10.1203/00006450-198808000-00002
Abstract
Mucosal immune defense responses in two clinical forms of enterocolitis complicating congenital me-gacolon in the piebald lethal mouse model of Hirschsprung's disease were investigated. Significant histological and immunocytochemical differences were seen in the ganglionic segment of colon between piebald mice with early clinical onset of acute illness and piebald mice with late onset enterocolitis. The number of IgA-containing plasma cells infiltrating the lamina propria of the gut in the former group were significantly increased (p < 0.001) compared to the latter group of mice and healthy controls. This study suggests that the two forms of enterocolitis complicating congenital megacolon in piebald mice have different etiologies.This publication has 1 reference indexed in Scilit:
- Selective depletion of substance P-immunoreactive neurones in the transitional zone of the colon in piebald lethal miceNeurochemistry International, 1984