COACERVATION PROPERTIES IN SEQUENTIAL POLYPEPTIDE MODELS OF ELASTIN
- 1 August 1978
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 12 (2) , 81-92
- https://doi.org/10.1111/j.1399-3011.1978.tb02871.x
Abstract
Syntheses of two sequential polypeptides H-(Ala-Pro-Gly-Gly)n-Val-OMe and H-(Ala-Pro-Gly-Val-Gly)n-Val-OMe via the p-nitrophenyl active ester procedure are reported. The two polymers were obtained in good yields and were of large MW, n > 40. These 2 polypeptides were synthesized as analogs of the two coacervating sequential polypeptides, H-(Val-Pro-Gly-Gly)n-Val-OMe, and H-(Val-Pro-Gly-Val-Gly)n-Val-OMe, in which the Val-l residue is replaced by an Ala-l residue. H-(Ala-Pro-Gly-Gly)n-Val-OMe did not coacervate even at as high a temperature as 100.degree. C, and H-(Ala-Pro-Gly-Val-Gly)n-Val-OMe did not coacervate; however, if precipitated irreversibly around 65-70.degree. C. This suggests the critical role of the Val-Pro hydrophobic side chain interaction in coacervation.Keywords
This publication has 22 references indexed in Scilit:
- NON‐ELASTOMERIC POLYPEPTIDE MODELS OF ELASTINInternational Journal of Peptide and Protein Research, 1978
- COACERVATION OF SEQUENTIAL POLYPEPTIDE MODELS OF TROPOELASTINInternational Journal of Peptide and Protein Research, 1978
- Synthesis of a cross‐linked polypentapeptide of tropoelastinBiopolymers, 1976
- Proton magnetic resonance and conformational energy calculations of repeat pepetides of tropoelastin: the tetrapeptideJournal of the American Chemical Society, 1976
- Racemization in the synthesis of polytripeptide models of collagenBiopolymers, 1976
- On the molecular mechanisms of elastin coacervation and coacervate calcificationFaraday Discussions of the Chemical Society, 1976
- Proton and carbon magnetic resonance studies of the synthetic polypentapeptide of elastinJournal of Molecular Biology, 1975
- Studies on the conformations and interactions of elastin. Proton magnetic resonance of the repeating tetramerBiopolymers, 1974
- Synthesis of polypeptides and oligopeptides with the repeating sequence L-alanyl-L-prolylglycineBiochemistry, 1971
- Polypeptides with Known Repeating Sequence of Amino Acids. Synthesis of Poly-L-glutamyl-L-alanyl-L-glutamic Acid and Polyglycylglycyl-L-phenylalanine through Pentachlorophenyl Active Ester1Journal of the American Chemical Society, 1966