Dissociation between interferon production induced by phytohemagglutinin and concanavalin A in spleen cell cultures of nude mice

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Abstract
Spleen cells of homozygous nude mice did not react with lymphoproliferation to both phytohemagglutinin (PHA) and concanavalin A (Con A), and there was no detectable interferon production in response to Con A. However, PHA‐induced interferon production was equal in spleen cells of nuinu mice and nu/+ mice. One possible explanation for these findings is that a subset of T cells responds to PHA with interferon production different from that responding to Con A with interferon production.