Influence of Primers on the Detection of TT Virus DNA by Polymerase Chain Reaction

Abstract
We read with great interest the article by Irving et al. [1] who showed different prevalence rates of TT virus (TTV) in patients with chronic hepatitis C by 3 PCR methods with primers deduced from distinct regions of the TTV genome [2–4]. TTV is a nonenveloped and single-stranded DNA virus isolated from a patient with posttransfsuion hepatitis of unknown cause [2, 5]. Because TTV has a circular genomic structure [6–8], it would be classified into the Circoviridae family.

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