Erythromelalgic, thrombotic and haemorrhagic manifestations of thrombocythaemia.

  • 22 January 1994
    • journal article
    • Vol. 23  (2) , 73-7
Abstract
In order to document a relationship between platelet counts and clinical complication of thrombosis or bleeding in patients with myeloproliferative thrombocythaemia, 200 consecutive published cases of thrombocythaemia were reviewed for thrombotic or haemorrhagic manifestations and haematological findings at the time of the thrombohaemorrhagic complication. Cases selected from the literature included all those complying with the diagnosis of thrombocythaemia as mandated by the Polycythemia Vera Study Group. One hundred consecutive cases of thrombocythaemia complicated by bleedings and one hundred consecutive cases of thrombocythaemia complicated by thrombosis were reviewed for clinical manifestations and haematological findings. In the reviewed cases of thrombocythaemia haemorrhagic complications (platelet count 2016 +/- 1070 x 10(9)/1) occurred at significantly (p < 0.001) higher degrees of thrombocytosis than thrombotic complications (platelet count 1110 +/- 477 x 10(9)/1). In the reviewed cases of thrombocythaemia arterial complications, especially erythromelalgia, can already be documented at platelet counts in excess of 400 x 10(9)/1, whereas bleeding complications usually occur at significantly higher degrees of thrombocytosis (> 1000 x 10(9)/1).

This publication has 0 references indexed in Scilit: