Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice.
Open Access
- 1 May 1989
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 9 (5) , 2254-2257
- https://doi.org/10.1128/mcb.9.5.2254
Abstract
We investigated the tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein by introducing the C3(1) gene with 4-kilobase (kb) upstream and 2-kb downstream flanking sequences into transgenic mice. There was selective expression in the ventral prostate that was stimulated by testosterone, which indicated that the gene together with 6-kb flanking DNA contains the information required for prostate-specific and testosterone-regulated expression.This publication has 24 references indexed in Scilit:
- Analysis of regulatory sequences in androgen-responsive genesJournal of Steroid Biochemistry, 1988
- Expression of androgen receptors and prostatic steroid-binding protein during development of the rat ventral prostateJournal of Endocrinology, 1988
- Position-independent, high-level expression of the human β-globin gene in transgenic miceCell, 1987
- Androgen receptor-binding regions of an androgen-responsive geneMolecular and Cellular Endocrinology, 1987
- STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKSAnnual Review of Genetics, 1985
- Androgen-regulated expression of a cloned rat prostatic C3 gene transfected into mouse mammary tumor cellsCell, 1983
- Effect of androgen on the transcription of rat prostatic binding protein genesMolecular and Cellular Endocrinology, 1982
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979
- RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexaminationBiochemistry, 1977
- Prostatic Binding Protein. A Steroid-Binding Protein Secreted by Rat ProstateEuropean Journal of Biochemistry, 1977