GONADOTROPIN RELEASE IN PATIENTS WITH ANDROGEN INSENSITIVITY - TESTICULAR FEMINIZATION SYNDROME

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 47  (3) , 331-336
Abstract
Two siblings are presented, both with classic androgen-insensitivity syndrome (AIS). Endocrine testing was carried out, and then gonadectomy was performed. Studies in these patients with AIS revealed low control serum FSH [follicle stimulating hormone]. In these patients serum FSH was not significantly suppressed by i.v. estrogen nor adequately stimulated by gonadotropin[FSH-LH]-releasing hormone but rose normally after castration. The various studies are interpreted in the light of the known kinetics of pituitary gonadotropins and their modulation by gonadal steroids. A 3rd sibling is also presented.