A useful method for α-methylation of γ-butyrolactones
- 1 January 1972
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 892-893
- https://doi.org/10.1039/c39720000892
Abstract
γ-Butyrolactone in tetrahydrofuran at –78° reacts with lithium di-isopropylamide or lithium iso-propylcyclohexylamide and then with an excess of deuterium oxide, methyl iodide, or allyl bromide to form α-deuterio-, α-methyl-, or α-allyl-γ-butyrolactone in good yield.Keywords
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