Development of IgM Antibody to Group B Streptococcus Type III in Human Infants
- 1 June 1992
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 165 (6) , 1049-1055
- https://doi.org/10.1093/infdis/165.6.1049
Abstract
An ELISA was developed to measure IgM antibody to albumin-coupled native capsular polysaccharide of type III group B streptococcus (GBS). The assay was standardized by two doublelabel methods that agreed within 33%. In quantitative assays, the range of IgM antibody to type III GBS in the sera of94 adult pregnant women was 1.2–50.6 µg/ml (median, 5.4), while each of 38 cord serum samples contained 7 months of age. The acquisition of specific IgM antibody is inversely correlated with the age-limited incidence of type III GBS infections in young children.Keywords
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