Abstract
A method of estimating and comparing histamine release by muscle relaxants in man is described.The results of a series of experiments using this technique suggest that d-tubocurarine chloride releases the largest amount of histamine and next come dimethyltubo-curarine iodide, gallamine triethiodide, and decamethonium iodide in that order.The controlled hypotension technique affords an opportunity of examining these facts clinically.

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