Modulation by prostaglandin E2 of ATP and noradrenaline co‐transmission in the guinea‐pig vas deferens

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Abstract
1. In the guinea-pig vas deferens, prostaglandin E2 (100 nM) enhanced the overflow of ATP, whereas it inhibited [3H]-noradrenaline overflow due to field stimulation at 2 Hz. At 20 Hz, prostaglandin E2 still inhibited the overflow of [3H]-noradrenaline, whereas it was without effect on ATP overflow. 2. Prostaglandin E2 enhanced contractions to exogenously added noradrenaline and alpha, beta-methylene ATP. 3. These results provide evidence for pre- and postjunctional modulation of purinergic and adrenergic transmission by PGE2 in the guinea-pig vas deferens. The importance of these findings in relation to co-transmission is discussed.