Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals
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Open Access
- 1 December 2006
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 21 (6) , 430-439
- https://doi.org/10.1152/physiol.00032.2006
Abstract
Lipid rafts are liquid-ordered (lo) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating lo-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.Keywords
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