Syrosingopine

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Abstract
RAUWOLFIA preparations have been widely accepted in the treatment of hypertension since they were introduced by Vakil1 in 1949 and Wilkins and his associates2 in 1952. They are simple to administer and have a wide margin of safety. Troublesome side effects of depression, lethargy, sedation, nasal congestion, increased appetite, nightmares, headaches and gastrointestinal symptoms have become well recognized. Depression, which is the most serious of these side effects, has reached the point of suicide in some cases. It may develop insidiously even after three years of treatment.The type and frequency of side effects and the blood-pressure response vary little . . .