RELATION OF THE CHANGES IN THE BRAIN TO THOSE IN THE SKULL OF CROUZONʼS AND SIMILAR DISEASES; WITH REPORT OF A CASE

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Abstract
Definite abnormalities in the brain were present 4 out of 25 necropsies in cases of Crouzon''s cranial facial dysarthrosis. Three of these were cases of acrocephalo-syndactylism. In 2, the corpus callosum was missing and there were local abnormalities of the gyral pattern. In the 3d case, there was an abnormality of the microscopic structure of the cerebellar cortex. In the 4th case, there was hypoplasia of one of the cerebral hemispheres. In 3 other cases, there was hydrocephalus which may or may not have been of developmental origin. In one case in which the brain was larger than normal, insufficient information was available to determine the nature of the abnormality. In most cases the only changes in the brain were those secondary to changes in the skull. Although in most cases symptoms referrable to the brain can be related to the skull changes, it is clear that a number of developmental changes in the brain are associated with malformations of the skull just as other anomalies such as syndactyly may be associated with them and it is to be expected that mental and possible neurogic symptoms will sometimes occur due to an associated anomaly of the brain.

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