Genetic variants of human erythrocyte glucose 6‐phosphate dehydrogenase: new variants in West Africa characterized by column chromatography

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Abstract
Five electrophoretically slow-moving genetic variants of glucose-6-phosphate dehydrogenase [G-6-PD] are described: 4 are from Nigeria and 1 is from Togo. All variants have normal or moderately reduced activity, and they are not associated with adverse clinical or hematological manifestations. Three variants were fully characterized and are different from all previously described ones. Two variants were partially characterized and at least 1 of them is also probably new. The overall population incidence of sporadic variants of G-6-PD in the Nigerian population is 0.3%. A previously described ion-exchange chromatographic technique for the characterization of G-6-PD variants was extensively evaluated. Data are given on 10 differnt variants to demonstrate the high resolving power of this technique.
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