Abstract
To characterize the development of adipose tissue in genetically obese and lean swine, adipose tissue metabolic activity and cellularity were examined at two stages of growth. In vitro lipogenesis at a constant age (100 days) revealed that fatty acid synthesis on a wet tissue basis was 33% greater for the obese line (DH) and 60% less for the lean line (DL) compared to the unselected control line (DC). When corrected for fat mass, synthesis was 256% greater and 84% less for the DH and DL lines, respectively, as compared to the DC line. In vitro lipogenesis at a constant weight (95 kg) showed the anticipated age dependent decrease of fatty acid synthesis by the DH and DC lines (85 and 77%, respectively). Corrected for adipose tissue depot, fatty acid synthesis was 78 and 15% greater for the DH and DL lines, respectively, as compared to the DC line. Between the sampling periods, adipose depot fatty acid synthesis was estimated to decrease by 22% for the DH line and increase by 56 and 1043% for the DC and DL lines, respectively. Copyright © 1974. American Society of Animal Science . Copyright 1974 by American Society of Animal Science.