Granuloma Necrosis during Mycobacterium avium Infection Does Not Require Tumor Necrosis Factor
Open Access
- 1 October 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (10) , 6139-6141
- https://doi.org/10.1128/iai.72.10.6139-6141.2004
Abstract
The infection of tumor necrosis factor (TNF)-deficient mice with low doses of the virulent Mycobacterium avium strain 25291 led to the appearance of necrotic granulomas at 93 days of infection, i.e., sooner than necrotic granulomas appeared in C57BL/6 animals. Additionally, TNF-deficient mice exhibited higher mycobacterial loads in the infected organs, had extremely exacerbated gamma interferon responses as evaluated in the sera of infected animals, and showed reduced survival. Thus, TNF is not required for granuloma necrosis.Keywords
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