A Comparison of Tc-99m-labeled Human Serum Albumin and In Vitro Labeled Red Blood Cells for Blood Pool Studies

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Abstract
99mTc-labeled human serum albumin (HSA) and in vitro labeled red blood cells (RBC) were compared in 5 subjects. The disappearance of radioactivity from the blood was more rapid for HSA (T 1/2 [half-life], 281.6 min, range 202.1-318.3) than for RBC (T 1/2, 1719.8 min, range 767.6-5059.5). Urinary excretion was twice as great for HSA. Ratios of activity in heart blood pool to lung and liver were considerably greater for RBC up to 2 h after administration. Labeled RBC are superior to labeled HSA for blood pool imaging. [This method is used for the evaluation of left ventricular ejection fraction.].

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