Influence of Carbon Dioxide on the MIC of Telithromycin for Streptococcus pneumoniae : an In Vitro - In Vivo Study
Open Access
- 1 January 2005
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (1) , 464-466
- https://doi.org/10.1128/aac.49.1.464-466.2005
Abstract
Incubation in CO 2 resulted in higher (≥3 doubling dilution) MICs of telithromycin than those found in ambient air for 31.2% of 346 Streptococcus pneumoniae ermB -positive strains. An increased telithromycin MIC in CO 2 was not correlated with loss of its activity in the murine sepsis/peritonitis model.Keywords
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