Inflammatory cell influx into ozone-exposed guinea pig lung interstitial and airways spaces
- 1 September 1991
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 34 (1-2) , 270-273
- https://doi.org/10.1007/bf01993300
Abstract
As a model of non-immunological lung inflammation, guinea pigs were exposed to 2.0 ppm ozone for 4 hours. Polymorphonuclear leukocytes (PMNs) rapidly accumulated in lung interstitium but declined from 147±34 million cells to control values (33±6 million cells) within the first 24 hours. Bronchoalveolar lavage (BAL) recovered PMNs were maximal by 3–6 hours (4±1 million cells) and remained elevated for 3 days. Macrophage numbers were doubled in lavageable spaces but those in interstitium increased by only a third at 2 days post-exposure. By 7 days post-exposure BAL macrophages had declined to control values of 12±2 million cells while those in interstitium remained elevated through 14 days. These data demonstrate that BAL does not necessarily reflect cellular changes in lung interstitium.Keywords
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