Effect of Very High-Intensity Statin Therapy on Regression of Coronary Atherosclerosis

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Abstract
Atherosclerosis is generally viewed as a chronic, progressive disease characterized by continuous accumulation of atheromatous plaque within the arterial wall. The last 2 decades have witnessed the introduction of a variety of antiatherosclerotic therapies, most notably the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins). Although statins rank among the most extensively studied therapies in contemporary medicine, the optimal target levels for low-density lipoprotein cholesterol (LDL-C) remain controversial. Recently, several active control trials have reported that more intensive statin therapy results in a greater reduction in adverse cardiovascular outcomes compared with more moderate treatment.1-3 Accordingly, guidelines now recommend achieving more aggressive target levels (an LDL-C level of 4

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