USE OF THA IN TREATMENT OF ALZHEIMER-LIKE DEMENTIA - PILOT-STUDY IN 12 PATIENTS
- 1 January 1981
- journal article
- research article
- Vol. 16 (2) , 145-153
Abstract
THA (1,2,3,4-tetrahydro-5aminoacridine) a centrally acting anticholinesterase, was given i.v. in varying doses to 12 unselected human cases of Alzheimer-like senile dementia. Significant improvement in memory testing occurred in 6 of 12 subjects; 9 of 12 improved in clinical staging. Analysis of results with respect to staging of dementia revealed that the degree of improvement was inversely related to the severity of dementia. Statistical analysis of these data by the Friedman test is detailed.This publication has 4 references indexed in Scilit:
- Choline chloride treatment of memory deficits in the elderlyAmerican Journal of Psychiatry, 1979
- Clinical Findings in Presenile Dementia A Report of 50 CasesJournal of Nervous & Mental Disease, 1979
- The Clinical Phenomenology of Presenile Dementia A Critical Review of the LiteratureJournal of Nervous & Mental Disease, 1979
- NEOCORTICAL CHOLINERGIC NEURONS IN ELDERLY PEOPLEThe Lancet, 1977