Metabolic Effects of Thyroxine, 3,3',5-Triiodothyronine, 3,3'-Diiodo-5-Bromothyronine and 3,3'-Diiodothyronine Administered Orally to Rats
- 31 October 1956
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 187 (2) , 323-327
- https://doi.org/10.1152/ajplegacy.1956.187.2.323
Abstract
By using large amounts of (–) thyroxine, (–) 3,3',5-triiodothyronine, (±) 3,3'-diiodo-5-bromothyronine and (±) 3,3'-diiodothyronine in the drinking water of rats, it was found that thyroxine, triiodothyronine and 3,3'-diiodo-5-bromothyronine elevated the metabolism while 3,3'-diiodothyronine had no effect with this method of administration. It was observed that there was a limiting value to the elevation of the metabolism which was soon reached with thyroxine but not with triiodothyronine. The maximal elevation of metabolism obtained with triiodothyronine was +244 in the thyroidectomized animal and +201 in the normal animal. With thyroxine the maximal metabolism was +141 in the thyroidectomized animal and +26 in the normal animal. One hypothyroid rat showed skin changes which healed after 11 days with triiodothyronine in the drinking water.Keywords
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