BASAL KINETIC-STUDIES OF TC-99M DMPE AS A MYOCARDIAL IMAGING AGENT IN THE DOG

  • 1 January 1982
    • journal article
    • research article
    • Vol. 23  (12) , 1093-1101
Abstract
Newly synthesized 99mTc dichlorbis(1,2-dimethylphosphino)ethane (DMPE) was investigated as a myocardial imaging agent with respect to its kinetics (dependent on both time and regional coronary blood flow), its percent organ uptake and its imaging characteristics in the anesthetized dogs. Most of these data are compared with those of 201Tl. Blood clearance of the 2 agents is essentially the same. Compared with 201Tl, 99mTc DMPE shows faster overall kinetics, higher heart-to-lung ratio, equally good correlation with a wide range of regional blood flows, and higher liver uptake. At the time of peak myocardial uptake, the mean heart uptake of 201Tl is 4.3%, compared with 2.9% for 99mTc DMPE, yet only 0.9% uptake of 99mTc DMPE is found in the lung as compared with 3.3% for 201Tl. These differences result in a heart-to-lung ratio of 2:1 for 99mTc DMPE and 1:1 for 201Tl, based on the data obtained from the time-activity curve. The quantitative findings are supported by the superior quality of 99mTc DMPE images of both normal and infarcted dog heart. The high hepatic uptake of 99mTc DMPE is not a serious problem if images are obtained within 5-60 min after dose. 99mTc DMPE is a promising myocardial imaging agent.