The effect of treating with anti‐interleukin‐1 receptor antibody on the course of experimental murine cutaneous leishmaniasis

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Abstract
SUMMARY: To assess the role of interleukin‐1 (IL‐1) in cutaneous leishmaniasis, Leishmania major‐infected mice were treated with an anti‐IL‐1 receptor monoclonal antibody, LA‐15.6. MoAb LA‐15.6 prevents binding of IL‐1 to both the T cell and B cell/macrophage forms of the IL‐1 receptor. We found that treating with LA 15.6 inhibited the development of cutaneous lesions of L. major in both genetically‐susceptible and resistant mice. Interestingly, this treatment had little or no effect on parasite numbers in the lesions or on the cytokines (interferon‐gamma, interleukin‐4) that the animals produced in response to infection with the parasite. These results suggest that although IL‐1 plays a detrimental role in cutaneous leishmaniasis, it does not mediate this effect by altering the parasite‐specific T cell response.

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