Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.
Open Access
- 1 August 1989
- journal article
- clinical trial
- Published by BMJ in British Journal of Ophthalmology
- Vol. 73 (8) , 604-607
- https://doi.org/10.1136/bjo.73.8.604
Abstract
Bromovinyldeoxyuridine is a potent and safe antiherpes compound that in combination with a placebo treatment promoted the partial and complete healing of herpetic epithelial disease in 22 patients in average times of 4-6 days and 8.5 days respectively. However, when BVDU was combined with 1.5 X 10(6) IU of recombinant a 2C interferon, partial and complete healing times for keratitis in 19 patients were reduced to 2-6 days and 4-6 days respectively. No toxic effects of the medications were observed in any patient.Keywords
This publication has 21 references indexed in Scilit:
- Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogsPharmacology & Therapeutics, 1984
- The antiviral spectrum of (E)-5-(2-bromovinyl)-2 '-deoxyuridineJournal of Antimicrobial Chemotherapy, 1984
- Comparative Efficacy of Antiberpes Drugs Against Various Strains of Varicella-Zoster VirusThe Journal of Infectious Diseases, 1983
- Oral and Topical Treatment of Experimental Herpes Simplex Iritis With BromovinyldeoxyuridineArchives of Ophthalmology (1950), 1982
- In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compoundsAntimicrobial Agents and Chemotherapy, 1982
- Inhibition of simian varicella virus infection of african green monkeys by (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU)Antiviral Research, 1981
- Efficacy of (E)-5-(2-bromovinyl)-2?-deoxyuridine in the topical treatment of herpes simplex keratitisAlbrecht von Graefes Archiv für Ophthalmologie, 1981
- Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex VirusThe Journal of Infectious Diseases, 1980
- (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.Proceedings of the National Academy of Sciences, 1979
- COMBINATION THERAPY OF DENDRITIC KERATITIS WITH TRIFLUOROTHYMIDINE AND INTERFERONThe Lancet, 1978